Differential effect of TPA on PGE2 and cicaprost-induced cAMP synthesis in UMR-106 cells.

@article{Khanin1999DifferentialEO,
  title={Differential effect of TPA on PGE2 and cicaprost-induced cAMP synthesis in UMR-106 cells.},
  author={Marina Khanin and Yair Liel and Gilad Rimon},
  journal={Cellular signalling},
  year={1999},
  volume={11 3},
  pages={
          165-9
        }
}
PGE2 and prostacyclin each enhance cAMP synthesis in the osteoblast-like cell line UMR-106. The amount of cAMP induced by PGE2 was 5-7-fold greater than the amount induced by cicaprost or iloprost, stable prostacyclin analogues. Both PGE2 and the two prostacyclin analogues enhanced cAMP synthesis with similar time dependence. The EC50 values of PGE2 and cicaprost were 3 X 10(-6) and 5 x 10(-8) M, respectively. Short-term incubation of the cells with 12-o-tetradecanoylphorbol 13-acetate (TPA… CONTINUE READING