Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.

@article{Fu2010DifferentialDA,
  title={Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.},
  author={Yu Fu and Z. Josh Huang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 52},
  pages={22699-704}
}
Neurexins (NRXs) and neuroligins are key synaptic adhesion molecules that also recruit synaptic signaling machineries. Neurexins consist of α- and β-isoforms, but how they couple synaptic transmission and adhesion to regulate activity-dependent synapse development remains unclear, in part because of poor understanding of their cell biology and regulation in the relevant neurons. Here, we examined the subaxonal localization, dynamics, and regulation of NRX1α and NRX1β in cortical perisomatic… CONTINUE READING

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