Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer.

@article{Strassburg1997DifferentialDO,
  title={Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer.},
  author={Christian P. Strassburg and Michael P. Manns and Robert H. Tukey},
  journal={Cancer research},
  year={1997},
  volume={57 14},
  pages={2979-85}
}
One of the most important processes controlling cellular detoxification is carried out in the endoplasmic reticulum by glucuronidation, and most likely plays an important role in the defense mechanism against chemical-induced carcinogenesis. The human UDP-glucuronosyltransferase UGT1A locus encodes up to 12 unique transferases that are transcribed through selective exon sharing. Little is known about how this locus is regulated in human tissues. We present evidence that the UGT1A gene products… CONTINUE READING

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