Differential distribution of purine metabolizing enzymes between glia and neurons.

  title={Differential distribution of purine metabolizing enzymes between glia and neurons.},
  author={Guillermo A Ceballos and Jeremy B. Tuttle and Rafael Rubio},
  journal={Journal of neurochemistry},
  volume={62 3},
Previous studies showed that in cultured chick ciliary ganglion neurons and CNS glia, adenosine can be synthesized by hydrolysis of 5'-AMP and that the accumulation of the adenosine degradative products inosine and hypoxanthine was significantly greater in glial than in neuronal cultures. Furthermore, previous immunochemical and histochemical studies in brain showed that adenosine deaminase and nucleoside phosphorylase are localized in endothelial and glial cells but are absent in neurons… CONTINUE READING
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