Differential distribution of glycine transporters in Müller cells and neurons in amphibian retinas

@article{Jiang2007DifferentialDO,
  title={Differential distribution of glycine transporters in M{\"u}ller cells and neurons in amphibian retinas},
  author={Zheng Jiang and Baoqin Li and Frantisek Jursky and Wen Shen},
  journal={Visual Neuroscience},
  year={2007},
  volume={24},
  pages={157 - 168}
}
Amphibian retinas are commonly used for electrophysiological studies on neural function and transduction because they share the same general properties as higher vertebrate retinas. Glycinergic synapses have been well described in amphibian retinas. However, the role of glycine transporters in the synapses is largely unknown. We studied the distribution and function of glycine transporters in the retinas from tiger salamanders, mudpuppies, and leopard frogs by immunofluorescence labeling and… Expand
Comparative electrophysiology of retinal Müller glial cells—A survey on vertebrate species
TLDR
A survey on Müller cell electrophysiology covering all classes of vertebrates is presented, mainly performed using the whole‐cell patch‐clamp technique, but data about the expression of membrane channels and transporters from immunohistochemistry are also included. Expand
Glycine input induces the synaptic facilitation in salamander rod photoreceptors.
TLDR
It is reported that glycinergic input enhances photoreceptor synapses in amphibian retinas and a new function of glycine in retinal synaptic transmission is revealed. Expand
Glycine transporters (glycine transporter 1 and glycine transporter 2) are expressed in retina
TLDR
In-situ hybridization signals were observed in the ganglionar and inner nuclear layer as well as in the outer nuclear layer of the frog and rat retinas and accumulation of 3H-glycine was observed in isolated photoreceptor cells. Expand
Role of retinal glial cells in neurotransmitter uptake and metabolism
TLDR
The present knowledge regarding the role of retinal glial cells in the uptake of glutamate, N-acetylaspartylglutamate, gamma-aminobutyric acid, glycine, and d-serine, as well as the degradation and removal of purinergic receptor agonists are summarized. Expand
Glycine transport accounts for the differential role of glycine vs. d‐serine at NMDA receptor coagonist sites in the salamander retina
In this study, we demonstrate that d‐serine interacts with N‐methyl‐d‐aspartate receptor (NMDAR) coagonist sites of retinal ganglion cells of the tiger salamander retina by showing that exogenousExpand
Functional expression of the glycine transporter 1 on bullfrog retinal cones
TLDR
Results show for the first time the functional expression of GlyT1 on bullfrog cones in bullfrog retinal slices. Expand
Effects of Histamine on Light Responses of Amacrine Cells in Tiger Salamander Retina
TLDR
Findings suggest that inhibitory interactions between strata of the IPL and within the classical receptive fields of the ganglion cells would be particularly sensitive to histamine released from retinopetal axons. Expand
Glycine transporter 1 modulates GABA release from amacrine cells by controlling occupancy of coagonist binding site of NMDA receptors.
TLDR
These findings demonstrate that coagonist modulation of glutamatergic input to GABAergic ACs via NMDARs is strongly reflected in the AC neuronal output and thus is critical in GABAergic signal transfer function in the inner retina. Expand
GlyT1 inhibitor reduces oscillatory potentials of the electroretinogram in rats
TLDR
It is concluded that inhibition of the GlyT 1 transporter in the retina causes ERG changes which may underlie recent reports of visual disturbance with GlyT1 inhibitors in clinical trials. Expand
D-serine: A study of its function and regulation in the retina
University of Minnesota Ph.D. dissertation. Major: Neuroscience. Advisor: Robert F. Miller, MD. 1 computer file (PDF); v, 130 pages. Ill. (some col.)

References

SHOWING 1-10 OF 56 REFERENCES
Pharmacological Properties of Glycine Transport in the Frog Retina
TLDR
The results indicate the presence of different glycine transporter isoforms in the frog retina, acting mainly through the classical inhibitory glycine system. Expand
Distribution of the glycine transporter glyt-1 in mammalian and nonmammalian retinae.
TLDR
In monkeys, cats, and rats, populations of cells which the authors interpret as being glycine-containing interplexiform cells expressed glyt-1: these cells lacked a content of glutamate, suggesting they are not bipolar cells. Expand
Expression of glycine and the glycine transporter Glyt-1 in the developing rat retina
TLDR
Diverse mechanisms and transient roles for glycine in the developing rat retina are suggested, including a subpopulation of amacrine cells are prominently immunoreactive for both glycine and glyt-1 in the adult rat retina. Expand
Excitatory Amino Acid Transporters of the Salamander Retina: Identification, Localization, and Function
TLDR
The diverse population of sEAAT transporter subtypes with unique localization and functional properties indicates that glutamate transporters play a wide variety of roles in retinal function and are likely to underlie both the uptake of glutamate by Müller cells and the glutamate-elicited chloride conductance involved in signal transduction by photoreceptors and bipolar cells. Expand
Immunocytochemical localization of glycine and glycine receptors in the retina of the frog Rana ridibunda
TLDR
Several isoforms of synaptic GlyRs involved with different synapses and inhibitory circuits are present in the frog retina, mainly in the inner plexiform layer. Expand
Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain.
TLDR
The close spatial association of GLYT1 and glutamatergic synapses strongly supports a role for this protein in neurotransmission mediated by NMDA receptors in the forebrain, and perhaps in other regions of the CNS. Expand
Glycinergic contacts in the outer plexiform layer of the Xenopus laevis retina characterized by antibodies to glycine, GABA, and glycine receptors
TLDR
It is suggested that glycine receptors at photoreceptor synapses are stimulated by glycine that diffuses from other sites, possibly from IPCs, consistent with available physiological studies of glycinergic effects in this retina. Expand
The glycine transporter GLYT2 is a reliable marker for glycine-immunoreactive neurons.
TLDR
The evidences indicate that the high content of glycine observed in some neurons in culture is indeed achieved by the concentrative task performed by GLYT2, and that GLyT2 can be used as a reliable marker for identification of glycina-enriched neurons. Expand
Light microscopic localization of putative glycinergic neurons in the larval tiger salamander retina by immunocytochemical and autoradiographical methods
TLDR
Gly‐IR can serve as a valid and reliable marker for glycine‐containing neurons in this retina and it is suggested that glycine serves as a transmitter for several morphologically distinct types of amacrine cell, an interplexiform cell, and perhaps a small percentage of Type II bipolar cells and ganglion cells. Expand
Glycine transporters are differentially expressed among CNS cells
TLDR
Immunoblots show that GLYT1 is expressed at the highest concentrations in the spinal cord, brainstem, diencephalon, and retina, and, in a lesser degree, to the olfactory bulb and brain hemispheres, whereas it is not detected in peripheral tissues. Expand
...
1
2
3
4
5
...