Differential distribution of dynamin isoforms in mammalian cells.

  title={Differential distribution of dynamin isoforms in mammalian cells.},
  author={Hong L Cao and Francisca S Molina Garc{\'i}a and Mark A. McNiven},
  journal={Molecular biology of the cell},
  volume={9 9},
Dynamins are 100-kDa GTPases that are essential for clathrin-coated vesicle formation during receptor-mediated endocytosis. To date, three different dynamin genes have been identified, with each gene expressing at least four different alternatively spliced forms. Currently, it is unclear whether these different dynamin gene products perform distinct or redundant cellular functions. Therefore, the focus of this study was to identify additional spliced variants of dynamin from rat tissues and to… CONTINUE READING
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