Differential distribution and covalent binding of two labeled forms of methyl-CCNU in the Fischer 344 rat

@article{Kramer2004DifferentialDA,
  title={Differential distribution and covalent binding of two labeled forms of methyl-CCNU in the Fischer 344 rat},
  author={Robert Arjen Kramer and Mary G. McMenamin and Michael R. Boyd},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={14},
  pages={150-155}
}
SummaryThe present study compares the organ distribution and covalent binding of MeCCNU labeled either within the carbamylating ([cyclohexyl-1-14C]MeCCNU; Chx-14C-MeCCNU) or alkylating ([2-chloroethyl-1,2-14C]MeCCNU; Cle-14C-MeCCNU) region of the compound in an animal model shown to be suitable for studying the nephrotoxicity of the nitrosoureas. Extraction of tissue homogenates with organic solvents of increasing polarity, and subsequent analysis of these extracts by HPLC showed fat to… 

Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?

TLDR
Mutagenicity information can play a significant role in evaluating sensitization potential as part of an ITS though careful attention needs to be made to ensure that any information is interpreted in the appropriate context.

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