Differential diagnosis of Alzheimer's disease

@article{Geldmacher1997DifferentialDO,
  title={Differential diagnosis of Alzheimer's disease},
  author={David S Geldmacher and Peter Whitehouse},
  journal={Neurology},
  year={1997},
  volume={48},
  pages={2S - 9S}
}
Article abstract-Accurate diagnosis of dementia is essential to provide appropriate treatment as well as patient and family counseling. It may be difficult to differentiate dementia from delirium. In addition, several features distinguish dementia from depression, but the two can coexist and the distinction may be uncertain. Dementias can be grouped into two categories: dementia that presents without prominent motor signs and dementia that presents with prominent motor signs. Dementias without… 
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References

SHOWING 1-10 OF 66 REFERENCES
Cortical Lewy body dementia: clinical features and classification.
Seven patients, aged 65-72 years, are described with dementia and cortical Lewy bodies. In one patient a Parkinsonian syndrome was followed by dementia and motor neuron disease. In the remaining six…
Neuropsychological deficits in vascular dementia vs Alzheimer's disease. Frontal lobe deficits prominent in vascular dementia.
TLDR
The Writing sub Test of the WAB, the Picture Arrangement subtest of the WAIS-R, and the Motor Performance sub test of the MDRS were the best discriminators of AD and VAD in the overall and severely affected populations.
Lewy body disease and dementia. A review.
TLDR
The English-language literature dealing with the clinical and pathological features of DLBD was reviewed and pathological material from the Canadian Brain Tissue Bank, Toronto, Ontario, was reviewed over a 2-year period from 1991 through 1993.
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 1994
TLDR
The clinical and pathological criteria for frontotemporal dementia are described and future studies may indicate that there is a spectrum of non-specific histology involving both, or alternatively, that each may reflect a distinct process governed by different genetic or molecular mechanisms.
Diffuse Lewy body disease: clinical features in 15 cases.
Fifteen cases of diffuse Lewy body disease were diagnosed on pathological grounds during a single year in one health district. The range and frequency of clinical features contrast strikingly with…
The natural history of Alzheimer's disease. Description of study cohort and accuracy of diagnosis.
TLDR
It is indicated that longitudinal follow-up of demented cases increases accuracy of diagnosis, and that detailed cognitive testing aids in early classification, in a natural history study of Alzheimer's disease.
The Lewy body variant of Alzheimer's disease
TLDR
The patients with LBs appeared to constitute a distinct neuropathologic and clinical subset of AD, the Lewy body variant (LBV), and there was an increase in essential tremor, bradykinesia, mild neck rigidity, and slowing of rapid alternating movements in the LBV group.
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology Confirmation of the Clinical Diagnosis of Alzheimer's Disease
TLDR
Despite the relatively high level of clinical diagnostic accuracy, further refinement of assessment batteries may facilitate distinction of non-AD dementias from AD.
A potential noninvasive neurobiological test for Alzheimer's disease.
TLDR
It is reported that patients diagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes.
Neuropsychological detection and characterization of preclinical Alzheimer's disease
TLDR
Results lend support to the notion of a preclinical phase of AD and indicate that this very early stage of AD is characterized by poor word-finding ability, abstract reasoning, and memory.
...
...