Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors.

@article{Salonen2010DifferentialDE,
  title={Differential developmental expression of transcription factors GATA-4 and GATA-6, their cofactor FOG-2 and downstream target genes in testicular carcinoma in situ and germ cell tumors.},
  author={J Sakari Salonen and Ewa Rajpert-De Meyts and Susanna Mannisto and John Nielsen and Niels Graem and Jorma Toppari and Markku Heikinheimo},
  journal={European journal of endocrinology},
  year={2010},
  volume={162 3},
  pages={625-31}
}
OBJECTIVE Testicular germ cell cancer is the most common malignancy among young males. The pre-invasive precursor, carcinoma in situ testis (CIS), presumably originates from arrested and transformed fetal gonocytes. Given that GATA transcription factors have essential roles in embryonic and testicular development, we explored the expression of GATA-4, GATA-6, cofactor friend of GATA (FOG)-2, and downstream target genes during human testis development and addressed the question whether changes… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours

  • J de Jong, H Stoop, +7 authors LH. Looijenga
  • Journal of Pathology
  • 2005

Similar Papers

Loading similar papers…