Differential development of neuronal physiological responsiveness in two human neural stem cell lines

@article{Donato2007DifferentialDO,
  title={Differential development of neuronal physiological responsiveness in two human neural stem cell lines},
  author={Roberta Donato and Erik A. Miljan and Susan J Hines and Sihem Aouabdi and Kenneth Pollock and Sara Patel and Frances A. Edwards and John D. Sinden},
  journal={BMC Neuroscience},
  year={2007},
  volume={8},
  pages={36 - 36}
}
Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to neurodegenerative disease. Overexpression of the myc family transcription factors in human primary cells from developing cortex and mesencephalon has produced two stable multipotential NSC lines (ReNcell VM and CX) that can be continuously expanded in monolayer culture. In the undifferentiated state, both ReNcell VM and CX are nestin positive and have resting membrane potentials of around -60… CONTINUE READING

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from mouse embryonic and adult fibroblast cultures by defined factors

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