Differential desensitization response of the neonatal and adult rat somatotroph to growth hormone-releasing hormone and phorbol ester.

Abstract

Elevated levels of circulating growth hormone (GH) in the perinatal animal may be caused in part by relative resistance to the desensitizing effects of GH secretagogues. We compared the effects of 4-day exposure of primary pituitary cell cultures from adult male and 2-day-old rats to GH-releasing hormone (GHRH; 10 nM) or 12-O-tetradecanoyl-phorbol-13… (More)

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@article{Collins1996DifferentialDR, title={Differential desensitization response of the neonatal and adult rat somatotroph to growth hormone-releasing hormone and phorbol ester.}, author={Brendan J. Collins and Marcel Szab{\'o} and Leona Cuttler}, journal={Molecular and cellular endocrinology}, year={1996}, volume={117 1}, pages={75-81} }