Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed inXenopus laevis oocytes

@article{Vibat1995DifferentialDP,
  title={Differential desensitization properties of rat neuronal nicotinic acetylcholine receptor subunit combinations expressed inXenopus laevis oocytes},
  author={Cecile Rose T. Vibat and Jos{\'e} A. Lasalde and Mark G. McNamee and Enrique L. M. Ochoa},
  journal={Cellular and Molecular Neurobiology},
  year={1995},
  volume={15},
  pages={411-425}
}
1. Chronic administration of nicotine up-regulates mammalian neuronal nicotinic acetylcholine receptors (nAChRs). A key hypothesis that explains up-regulation assumes that nicotine induces desensitization of receptor function. This is correlated with behaviorally expressed tolerance to the drug. 2. The present experiments were conducted to: (a) obtain information on the nicotine-induced desensitization of neuronal nAChR function, a less understood phenomenon as compared to that of the muscle… CONTINUE READING