Differential depletion of total T cells and regulatory T cells and prolonged allotransplant survival in CD3Ɛ humanized mice treated with polyclonal anti human thymocyte globulin

@inproceedings{Buszko2017DifferentialDO,
  title={Differential depletion of total T cells and regulatory T cells and prolonged allotransplant survival in CD3Ɛ humanized mice treated with polyclonal anti human thymocyte globulin},
  author={Maja Buszko and Benno Cardini and Rupert Oberhuber and Lukas Oberhuber and Bojana Jakic and Anja Beierfuss and Georg Wick and Giuseppe Cappellano},
  booktitle={PloS one},
  year={2017}
}
Thymoglobulin (ATG) is a polyclonal rabbit antibody against human thymocytes used as a T cell-depleting agent to prevent or treat allotransplant rejection. The aim of the present study was to investigate the effect of low dose ATG treatment exclusively on T cells using a humanized BALB/c human CD3Ɛ transgenic mouse model expressing both human and murine T cell receptors (TCR). Mice received a single intravenous (i.v.) injection of ATG. Blood and peripheral lymphoid organs were obtained after… CONTINUE READING