Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations.

@article{Torres1997DifferentialDO,
  title={Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations.},
  author={Corine Torres and Akiko Iwasaki and Brian H. Barber and Harriet L Robinson},
  journal={Journal of immunology},
  year={1997},
  volume={158 10},
  pages={4529-32}
}
Surgical ablations revealed different dependencies on the injection site tissue for i.m. needle and epidermal gene gun DNA immunizations. Excision of an injected muscle bundle within 10 min of DNA inoculation did not affect the magnitude or longevity of Ag-specific Ab responses. By contrast, biopsy of the skin target site up to 24 h after gene gun bombardment completely abrogated the Ab response in the majority of mice. The form of a DNA-expressed Ag (membrane bound, secreted, or intracellular… CONTINUE READING

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