Differential dependence of LTD on glutamate receptors in the auditory cortical synapses of cortical and thalamic inputs.

@article{Kudoh2002DifferentialDO,
  title={Differential dependence of LTD on glutamate receptors in the auditory cortical synapses of cortical and thalamic inputs.},
  author={Masaharu Kudoh and Masashi Sakai and Katsuei Shibuki},
  journal={Journal of neurophysiology},
  year={2002},
  volume={88 6},
  pages={
          3167-74
        }
}
Pyramidal neurons in the auditory cortex (AC) receive glutamatergic inputs from the medial geniculate body (MGB inputs) and other pyramidal neurons (pyramidal inputs). We found that the induction of long-term depression (LTD) in supragranular layers was only partially suppressed by 50 microM D-(-)-2-amino-5-phosphonovalerate (APV), an antagonist of N-methyl-D-aspartate (NMDA) receptors (NMDARs), and 500 microM (+)-alpha-methyl-4-carboxyphenylglycine (MCPG), an antagonist of metabotropic… CONTINUE READING
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