Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice.

@article{Willard2015DifferentialDO,
  title={Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice.},
  author={Amanda Willard and Rachel S Bouchard and Aryn H Gittis},
  journal={Neuroscience},
  year={2015},
  volume={301},
  pages={254-67}
}
Parkinson's disease (PD) is a movement disorder whose cardinal motor symptoms arise due to the progressive loss of dopamine. Although this dopamine loss typically progresses slowly over time, currently there are very few animal models that enable incremental dopamine depletion over time within the same animal. This type of gradual dopamine depletion model would be useful in studies aimed at the prodromal phase of PD, when dopamine levels are pathologically low but motor symptoms have not yet… CONTINUE READING