Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles.

@article{Gibson1986DifferentialCA,
  title={Differential cytotoxicity and DNA-damaging effects produced in human cells of the Mer+ and Mer- phenotypes by a series of alkyltriazenylimidazoles.},
  author={Neil W. Gibson and John A. Hartley and R J La France and Keith Vaughan},
  journal={Carcinogenesis},
  year={1986},
  volume={7 2},
  pages={259-65}
}
A series of alkyltriazenylimidazoles have been investigated for their differential cytotoxicity towards the HT-29 (Mer+) and BE (Mer-) cell lines and for their ability to cause DNA strand breaks and cross-links. A monomethyltriazene, and some hydroxymethyltriazene derivatives capable of generating the monomethyltriazene in situ, were preferentially cytotoxic towards the BE cell line compared with the HT-29 cell line, with very close similarity in the differential toxicity to the analogous… CONTINUE READING