Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution.

@article{Bullock2004DifferentialCM,
  title={Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution.},
  author={Simon L Bullock and Michael Stauber and Alexander Prell and Julian Richard Hughes and D. Ish-Horowicz and Urs Schmidt-Ott},
  journal={Development},
  year={2004},
  volume={131 17},
  pages={4251-61}
}
Establishment of segmental pattern in the Drosophila syncytial blastoderm embryo depends on pair-rule transcriptional regulators. mRNA transcripts of pair-rule genes localise to the apical cytoplasm of the blastoderm via a selective dynein-based transport system and signals within their 3'-untranslated regions. However, the functional and evolutionary significance of this process remains unknown. We have analysed subcellular localisation of mRNAs from multiple dipteran species both in situ and… CONTINUE READING

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