Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.

@article{Corral1999DifferentialCM,
  title={Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.},
  author={Laura G. Corral and Patrick A. J. Haslett and George W. Muller and R H Chen and Lu Min Wong and Christopher Ocampo and Rebecca T. Patterson and David I. Stirling and Gilla Kaplan},
  journal={Journal of immunology},
  year={1999},
  volume={163 1},
  pages={380-6}
}
TNF-alpha mediates both protective and detrimental manifestations of the host immune response. Our previous work has shown thalidomide to be a relatively selective inhibitor of TNF-alpha production in vivo and in vitro. Additionally, we have recently reported that thalidomide exerts a costimulatory effect on T cell responses. To develop thalidomide analogues with increased anti-TNF-alpha activity and reduced or absent toxicities, novel TNF-alpha inhibitors were designed and synthesized. When a… CONTINUE READING
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