Differential cytokine contributions of perivascular haematopoietic stem cell niches

  title={Differential cytokine contributions of perivascular haematopoietic stem cell niches},
  author={Noboru Asada and Yuya Kunisaki and Halley Pierce and Zichen Wang and Nicolas F. Fernandez and Alexander Birbrair and Avi Ma'ayan and Paul S Frenette},
  booktitle={Nature Cell Biology},
Arterioles and sinusoids of the bone marrow (BM) are accompanied by stromal cells that express nerve/glial antigen 2 (NG2) and leptin receptor (LepR), and constitute specialized niches that regulate quiescence and proliferation of haematopoietic stem cells (HSCs). However, how niche cells differentially regulate HSC functions remains unknown. Here, we show that the effects of cytokines regulating HSC functions are dependent on the producing cell sources. Deletion of chemokine C-X-C motif ligand… CONTINUE READING
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