Differential cytokine and transcription factor expression in patients with allergic reactions to drugs.

@article{CornejoGarca2007DifferentialCA,
  title={Differential cytokine and transcription factor expression in patients with allergic reactions to drugs.},
  author={Jos{\'e} Antonio Cornejo-Garc{\'i}a and T D Fernandez and Mar{\'i}a Jos{\'e} Alvarez Torres and Modesto Carballo and Imma Hernan and Cristina Ant{\'u}nez and Miguel Blanca and Cristobalina Mayorga},
  journal={Allergy},
  year={2007},
  volume={62 12},
  pages={1429-38}
}
BACKGROUND Allergic drug reactions (ADR) can be either immediate reaction (IR) (IgE mediated) or delayed reaction (DR) (T-cell mediated). They follow the Th1/Th2 paradigm, with DR expressing interferon-gamma (IFN-gamma) with down-regulation of interleukin-4 (IL-4) and IR expressing IL-4 with down-regulation of IFN-gamma. We studied the extension of this polarization in DR and IR by examining the cytokine and transcription factor profile in T-cell subpopulations during the acute phase of an ADR… CONTINUE READING