Differential coupling of the PAC1 SV1 splice variant on human colonic tumors to the activation of intracellular cAMP but not intracellular Ca2+ does not activate tumor proliferation

@article{Germano2004DifferentialCO,
  title={Differential coupling of the PAC1 SV1 splice variant on human colonic tumors to the activation of intracellular cAMP but not intracellular Ca2+ does not activate tumor proliferation},
  author={Patrizia M. Germano and Sang V. Le and David S. Oh and Robert S Fan and Sandy N. Lieu and Alan Siu and Joseph R Pisegna},
  journal={Journal of Molecular Neuroscience},
  year={2004},
  volume={22},
  pages={83-91}
}
PAC1 is a recently cloned and characterized heptahelical, G protein-coupled receptor with high affinity to PACAP-27 and PACAP-38 and is differentially coupled to activate intracellular Ca2+ and cAMP. PAC1 is expressed as four major splice variants, each possessing differential coupling to inositol phosphates and intracellular Ca2+. PAC1 has been shown previously to be expressed and regulate the growth and proliferation of nonsquamous cell lung cancer cells, as well as breast cancer cell lines… CONTINUE READING
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Expression of pituitary adeylate cyclase-activating 16 polypeptide and PACAP type I receptor in the rat gastric and colonic myenteric

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1 Excerpt

Expression of pituitary adeylate cyclaseactivating 16 polypeptide and PACAP type I receptor in the rat gastric and colonic myenteric neurons

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Characterization of the pharmacology , signal transduction and internalization of the fluorescent PACAP ligand , fluorPACAP , on NIH / 3 T 3 cells expressing PAC 1

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Characterization of the pharmacology, signal transduction and internalization of the fluorescent PACAP ligand, fluor-PACAP, on NIH/3T3 cells expressing PAC1. Peptides22,861–866

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