Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease.

@article{Dournaud1995DifferentialCB,
  title={Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease.},
  author={Pascal Dournaud and Pia Dela{\`e}re and J. J. Hauw and Jacques Epelbaum},
  journal={Neurobiology of aging},
  year={1995},
  volume={16 5},
  pages={817-23}
}
The relationships between neurofibrillary tangles (NFT), senile plaques (SP), and the deficits in somatostatin (SRIH) and choline acetyltransferase (ChAT) levels were determined in Brodmann area 9, 40, 22, and 17/18 in 12 women whose Blessed test score (BTS) ranged from 27 to 1. NFT density correlated with the cognitive decline in areas 9, 40, and 22 and with SP number in area 22 and 17/18. ChAT levels were linked to the BTS in area 9, 40, and 22 and SRIH levels in area 9 only. ChAT, but not… CONTINUE READING

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