Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure

  title={Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure},
  author={Ellen Siobhan Mitchell and Marieke Slettenaar and Nosheen Meer and Catherine Transler and Linda A.W. Jans and Frits Quadt and Michael W. Berry},
  journal={Physiology \& Behavior},

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Effects of Theobromine and Caffeine on Mood and Vigilance

Findings indicate theobromine does not influence mood and vigilance when administered in nutritionally relevant doses, despite sharing many of caffeine’s structural characteristics.

Psychopharmacology of theobromine in healthy volunteers

It is concluded that theobromine at normal intake ranges may contribute to the positive effects of chocolate, but at higher intakes, effects become negative.

Ergogenic Effects of Intake of Salbutamol, Caffeine and Theobromine on Non-Asthmatic Subjects

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Exploring cocoa properties: is theobromine a cognitive modulator?

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Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies.

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The relevance of theobromine for the beneficial effects of cocoa consumption

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Reinforcing effects of caffeine and theobromine as found in chocolate

Methylxanthines in amounts found in 50-g chocolate may well contribute to the authors' liking for chocolate, especially to the more acquired taste for dark chocolate.

Methylxanthines are the psycho-pharmacologically active constituents of chocolate

A normal portion of chocolate exhibits psychopharmacological activity, and the identical profile of effects exerted by cocoa powder and its methylxanthine constituents shows this activity to be confined to the combination of caffeine and theobromine.

Discriminative stimulus and subjective effects of theobromine and caffeine in humans

It is suggested that commonly consumed cocoa products contain behaviorally active doses of caffeine and possibly theobromine, as well as other drugs, which are known to produce discriminative effects in humans.

Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat

Theobromine, a substance with less significant adenosine antagonist properties, had minimal effects on local cerebral blood flow and glucose utilization at a dose of 1.6 μmol/kg/min i.v, which may provide supportive evidence for the hypothesis thatAdenosine plays an important role in cerebral bloodflow-metabolism coupling.

Association between ADORA2A and DRD2 Polymorphisms and Caffeine-Induced Anxiety

Ass associations between self-reported anxiogenic effects of caffeine and variation in the genes for A2A (ADORA2A) and DRD2 (DRD2) receptors are examined to provide support for an association between an ADORA 2A polymorphism and self- reported anxiety after a moderate dose of caffeine.

Behavioral effects of cocoa and its main active compound theobromine: evaluation by ambulatory activity and discrete avoidance in mice.

  • H. KuribaraS. Tadokoro
  • Chemistry, Biology
    Arukoru kenkyu to yakubutsu izon = Japanese journal of alcohol studies & drug dependence
  • 1992
The present results indicate that the CNS action of theobromine may be received through consumption of the Obromine-containing foodstuffs or beverages in the authors' every day life.

Absorption rate of methylxanthines following capsules, cola and chocolate

The results suggest that a usual dietary portion of the cola or chocolate used in this study would produce behaviorally discriminable plasma levels of caffeine in most subjects and of theobromine in at least one subject.

Comparative stimulant and diuretic actions of caffeine and theobromine in man

Caffeine altered self‐estimates of sleep latency and sleep quality in a dose‐dependent fashion and increased overnight urinary sodium excretion and theobromine in equivalent doses had no detectable effect on sleep parameters or on urine composition.

Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users

It is confirmed that acute doses of caffeine, at levels typically found in a cup of coffee, produce stimulant-like subjective effects and enhance performance in light, nondependent caffeine users, supporting the idea that the drug has psychoactive effects even in the absence of withdrawal.