Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of dihydropyridine-receptor arrays in skeletal muscle.

@article{Takekura2004DifferentialCO,
  title={Differential contribution of skeletal and cardiac II-III loop sequences to the assembly of dihydropyridine-receptor arrays in skeletal muscle.},
  author={Hiroaki Takekura and Cecilia Paolini and Clara Franzini-armstrong and Gerlinde Kugler and M. Grabner and Bernhard E Flucher},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 12},
  pages={
          5408-19
        }
}
The plasmalemmal dihydropyridine receptor (DHPR) is the voltage sensor in skeletal muscle excitation-contraction (e-c) coupling. It activates calcium release from the sarcoplasmic reticulum via protein-protein interactions with the ryanodine receptor (RyR). To enable this interaction, DHPRs are arranged in arrays of tetrads opposite RyRs. In the DHPR alpha(1S) subunit, the cytoplasmic loop connecting repeats II and III is a major determinant of skeletal-type e-c coupling. Whether the essential… CONTINUE READING