Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation.

@article{Fossati2013DifferentialCO,
  title={Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation.},
  author={Silvia Fossati and Krysti Todd and Krystal Sotolongo and Jorge Ghiso and Agueda Rostagno},
  journal={The Biochemical journal},
  year={2013},
  volume={456 3},
  pages={347-60}
}
Mutations within the Aβ (amyloid β) peptide, especially those clustered at residues 21-23, are linked to early-onset AD (Alzheimer's disease) and primarily associated with cerebral amyloid angiopathy. The Iowa variant, a substitution of an aspartic acid residue for asparagine at position 23 (D23N), associates with widespread vascular amyloid and abundant diffuse pre-amyloid lesions significantly exceeding the incidence of mature plaques. Brain Iowa deposits consist primarily of a mixture of… CONTINUE READING
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