Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle.

@article{Naito2013DifferentialCO,
  title={Differential contribution of insulin and amino acids to the mTORC1-autophagy pathway in the liver and muscle.},
  author={Takako Naito and A. C. S. Kuma and Noboru Mizushima},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 29},
  pages={21074-81}
}
Autophagy is a highly inducible intracellular degradation process. It is generally induced by nutrient starvation and suppressed by food intake. Mammalian (or mechanistic) target of rapamycin complex 1 (mTORC1) is considered to be the major regulator of autophagy, but the precise mechanism of in vivo regulation remains to be fully characterized. Here, we examined the autophagy-suppressive effect of glucose, insulin, and amino acids in the liver and muscle in mice starved for 1 day. Refeeding… CONTINUE READING
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