Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemia.

@article{WalkerBrown2009DifferentialCO,
  title={Differential contribution of beta-adrenergic receptors expressed on radiosensitive versus radioresistant cells to protection against inflammation and mortality in murine endotoxemia.},
  author={Jill Walker-Brown and Margo R. Roberts},
  journal={Shock},
  year={2009},
  volume={32 5},
  pages={
          541-7
        }
}
  • Jill Walker-Brown, Margo R. Roberts
  • Published in Shock 2009
  • Medicine
  • The sympathetic nervous system modulates immune responses via the secretion of catecholamines and subsequent activation of adrenergic receptors (ARs), and systemic catecholamine levels increase markedly in the setting of endotoxemia and sepsis. Previous studies have demonstrated that stimulation of beta-ARs by pharmacological agonists attenuates the inflammatory response to LPS observed in vitro and can increase survival in animal models of endotoxemia and sepsis. However, the consequences of… CONTINUE READING

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