Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.

@article{Liu2012DifferentialCF,
  title={Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.},
  author={Gong-Xin Liu and B R Choi and Ohad Ziv and Weiyan Li and Enno de Lange and Zhilin Qu and Gideon Koren},
  journal={The Journal of physiology},
  year={2012},
  volume={590 5},
  pages={1171-80}
}
Early after-depolarization (EAD), or abnormal depolarization during the plateau phase of action potentials, is a hallmark of long-QT syndrome (LQTS). More than 13 genes have been identified as responsible for LQTS, and elevated risks for EADs may depend on genotypes, such as exercise in LQT1 vs. sudden arousal in LQT2 patients. We investigated mechanisms underlying different high-risk conditions that trigger EADs using transgenic rabbit models of LQT1 and LQT2, which lack I(Ks) and I(Kr) (slow… CONTINUE READING

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