Differential cognitive deterioration in dementia: a two year longitudinal study.

@article{Chamberlain2011DifferentialCD,
  title={Differential cognitive deterioration in dementia: a two year longitudinal study.},
  author={Samuel R. Chamberlain and Andrew. Blackwell and Pradeep J. Nathan and Geoffrey R. Hammond and Trevor William Robbins and John R. Hodges and Albert Michael and James Semple and Edward T. Bullmore and Barbara Jacquelyn Sahakian},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={24 1},
  pages={
          125-36
        }
}
The ability to predict cognitive deterioration in patients with dementia holds valuable potential for clinical trials and early intervention. This study identified cognitive domains deteriorating differentially over time as well as baseline predictors of subsequent cognitive decline in patients referred to a memory clinic. Twenty-six subjects with Alzheimer's disease (AD) and 43 subjects with Subjective Memory Impairment (SMI) were entered into a longitudinal study in which cognitive function… 

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References

SHOWING 1-10 OF 41 REFERENCES
Mild cognitive impairment: clinical characterization and outcome.
TLDR
Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
Detecting Dementia: Novel Neuropsychological Markers of Preclinical Alzheimer’s Disease
TLDR
Diagnostic outcome data is reported and a simple algorithm is described for calculating, with 100% accuracy for this sample of 40 patients, the probability that an individual with mild memory impairments will go on to receive a diagnosis of probable AD.
Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study
TLDR
Dementia may take many years to develop in patients with MCI but was a universal feature in this study and is discussed in the light of current views of MCI.
Paired associate performance in the early detection of DAT
TLDR
Performance on the CANTAB paired associate learning subtest identified the onset of progressive memory deterioration in a subgroup of QD subjects, and may be a valuable tool for the early, preclinical detection and assessment of DAT.
Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks
TLDR
A visuo-spatial associative learning test accurately distinguished AD from depressed/control subjects and revealed an apparent sub-group of QD patients who performed like AD patients, correlated with the degree of subsequent global cognitive decline.
A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease.
TLDR
The utility of the comparison between DAT and PD in characterizing the nature of the cognitive deficits in these conditions and their relation to those findings from animal neuropsychology which use comparable paradigms are discussed.
Dropouts and refusals in observational studies
TLDR
Observations suggest that dropouts and refusals in prevention trials include those subjects who are at high risk for progression to AD/dementia and targeted strategies to retain these individuals within prevention studies will be needed to achieve sufficient study power and validity.
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
TLDR
The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer’s disease; these criteria will be revised as more definitive information becomes available.
Predictive Factors of Attrition in a Cohort of Alzheimer Disease Patients
TLDR
The identification of both patient and caregiver factors predictive of attrition is of particular interest for the development and targeting of attrition prevention strategies in patients with chronic diseases, and particular attention should be paid to caregiver well-being to limit attrition.
...
1
2
3
4
5
...