Differential clustering of CD4 and CD3zeta during T cell recognition.

  title={Differential clustering of CD4 and CD3zeta during T cell recognition.},
  author={Matthew F Krummel and Michael D. Sjaastad and Christoph W{\"u}lfing and Mark M. Davis},
  volume={289 5483},
Whereas T helper cells recognize peptide-major histocompatibility complex (MHC) class II complexes through their T cell receptors (TCRs), CD4 binds to an antigen-independent region of the MHC. Using green fluorescent protein-tagged chimeras and three-dimensional video microscopy, we show that CD4 and TCR-associated CD3zeta cluster in the interface coincident with increases in intracellular calcium. Signaling-, costimulation-, and cytoskeleton-dependent processes then stabilize CD3zeta in a… CONTINUE READING


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