Differential class III antiarrhythmic effects of ambasilide and dofetilide at different extracellular potassium and pacing frequencies.

@article{Gjini1996DifferentialCI,
  title={Differential class III antiarrhythmic effects of ambasilide and dofetilide at different extracellular potassium and pacing frequencies.},
  author={V Gjini and Michael Korth and Juergen Schreieck and Sonja Weyerbrock and Albert Schoemig and Claude Schmitt},
  journal={Journal of cardiovascular pharmacology},
  year={1996},
  volume={28 2},
  pages={314-20}
}
We studied the effect of two new class II antiarrhythmics, ambasilide and dofetilide, on the action potential duration (APD) of guinea pig right ventricular papillary muscle at different extracellular potassium concentrations ([K+e]) and pacing frequencies. Under normal [K+e], both drugs significantly prolonged APD90 (APD at 90% repolarization) at 0.5 Hz. The effect of ambasilide was well preserved at rapid pacing rates, independent of [K+e]. The effect of dofetilide was markedly reduced with… CONTINUE READING

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