Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.

@article{Horikawa2005DifferentialCO,
  title={Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element.},
  author={Izumi Horikawa and Yungping Jeffrey Chiang and Tricia Patterson and L. Feigenbaum and Sun-Hee Leem and Eriko Michishita and Vladimir L. Larionov and Richard J Hodes and Jeffrey C. Barrett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 51},
  pages={18437-42}
}
In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire hTERT (human telomerase reverse transcriptase) gene was introduced in mice. In these transgenic mice, expression of the hTERT transgene was similar to that of endogenous hTERT in humans, rather than endogenous mTERT (mouse telomerase reverse transcriptase). In tissues and cells showing a striking… CONTINUE READING

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