Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.

@article{Mathers2009DifferentialCO,
  title={Differential capability of human cutaneous dendritic cell subsets to initiate Th17 responses.},
  author={Alicia Mathers and Brian M. Janelsins and J Peter Rubin and Olga A. Tkacheva and William J. Shufesky and Simon C. Watkins and Adrian E Morelli and Adriana T. Larregina},
  journal={Journal of immunology},
  year={2009},
  volume={182 2},
  pages={921-33}
}
Human skin-migratory dendritic cells (DCs) have the ability to prime and bias Th1 and Th2 CD4+ T lymphocytes. However, whether human cutaneous DCs are capable of initiating proinflammatory Th17 responses remains undetermined. We report that skin-migratory DCs stimulate allogeneic naive CD4+ T cells that differentiate simultaneously into two distinct effector Th17 and Th1 populations capable of homing to the skin, where they induce severe cutaneous damage. Skin-migratory Langerhans cells (smiLCs… CONTINUE READING

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