Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart.

@article{Rossow2006DifferentialCA,
  title={Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart.},
  author={Charles F. Rossow and Keith W. Dilly and Luis Fernando Santana},
  journal={Circulation research},
  year={2006},
  volume={98 10},
  pages={
          1306-13
        }
}
Kv4 channels are differentially expressed across the mouse left ventricular free wall. Accordingly, the transient outward K+ current (Ito), which is produced by Kv4 channels, is greater in left ventricular epicardial (EPI) than in endocardial (ENDO) cells. However, the mechanisms underlying heterogeneous Kv4 expression in the heart are unclear. Here, we tested the hypothesis that differential [Ca2+]i and calcineurin/NFATc3 signaling in EPI and ENDO cells contributes to the gradient of Ito… CONTINUE READING

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