Differential brain-derived neurotrophic factor and transforming growth factor-beta expression in the rat cochlea following deafness.

Abstract

Brain derived neurotrophic factor (BDNF) and transforming growth factor-beta (TGFbeta) subtypes have demonstrated their importance in cochlear functions. The aim of this study was to determine gene and protein expression patterns of BDNF, TGFbeta1/2 and their main receptors trkB and TGFbetaR1/R2 in the auditory nerve and inferior colliculus of normal hearing and deafened rats by reverse-transcriptase polymerase chain reaction and immunohistochemistry. Deafening was performed by cochlear injection of neomycin (10%). Significant gene expression changes were not found in the inferior colliculus after deafness; however, in the auditory nerve, BDNF, TGFbeta1 and TGFbetaR1 mRNA in particular were upregulated. Additionally, BDNF protein and the cytokines were found to be expressed in the auditory nerve after hair cell loss. These data indicate the importance of BDNF and TGFbeta1 as endogenous survival factors.

Statistics

0500100015002011201220132014201520162017
Citations per Year

170 Citations

Semantic Scholar estimates that this publication has 170 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wissel2006DifferentialBN, title={Differential brain-derived neurotrophic factor and transforming growth factor-beta expression in the rat cochlea following deafness.}, author={Kirsten Wissel and Patrick Wefstaedt and Josef M. Miller and Thomas Lenarz and Timo St{\"{o}ver}, journal={Neuroreport}, year={2006}, volume={17 12}, pages={1297-301} }