Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B.

@article{Micco2013DifferentialBO,
  title={Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B.},
  author={Lorenzo Micco and Dimitra Peppa and Elisabetta Loggi and Anna K C Schurich and Lucy Jefferson and Carmela Cursaro and Arianna Martello Panno and Mauro Bernardi and Christian Brander and Florian Bihl and Pietro Andreone and Mala K Maini},
  journal={Journal of hepatology},
  year={2013},
  volume={58 2},
  pages={225-33}
}
BACKGROUND & AIMS A better understanding of the immunomodulatory effects of PegIFNα therapy could allow more rational optimisation of future therapeutic approaches in chronic HBV infection. In this study, we evaluated dynamic changes in the innate and adaptive arms of the immune system induced by PegIFNα. METHODS PBMC were obtained from a cohort of patients with eAg-negative CHB before, during and after PegIFNα treatment. The number, phenotype and function of global and virus-specific T cells… CONTINUE READING