Differential blocking effects of prazosin and yohimbine on pressor responses to neuronally released and exogenously administered noradrenaline in the pithed rat.

The effects of prazosin and yohimbine on pressor responses to sympathetic nerve stimulation and intravenous injections of noradrenaline, phenylephrine and clonidine were examined in pithed rats to determine the postjunctional location of alpha 2-adrenoceptors in the vascular smooth muscle. Prazosin antagonized the pressor responses to phenylephrine and to… CONTINUE READING