Differential biological significance of tissue-type and urokinase-type plasminogen activator in human breast cancer.


Plasminogen activator (PA) is a serine protease existing in two forms known as tissue-type (t-PA) and urokinase-type (u-PA). To examine whether PA is related to the postoperative clinical course of human breast cancer, total PA activity, t-PA activity, u-PA activity, and immunoreactive t-PA were determined in tissue extracts from 144 breast cancer specimens… (More)
DOI: 10.1038/bjc.1993.380

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