Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.

@article{Ressing1999DifferentialBO,
  title={Differential binding of viral peptides to HLA-A2 alleles. Implications for human papillomavirus type 16 E7 peptide-based vaccination against cervical carcinoma.},
  author={Maaike E Ressing and Joan H de Jong and R P Brandt and Jan Wouter Drijfhout and Willemien E. Benckhuijsen and Geziena M Th Schreuder and Rienk Offringa and Wijbe Martin Kast and Cornelis J. M. Melief},
  journal={European journal of immunology},
  year={1999},
  volume={29 4},
  pages={1292-303}
}
Several cancer immune intervention protocols aim at inducing T cell immunity against antigens presented by HLA-A2, the most common human MHC class I molecule. In the context of HLA-A*0201, we previously identified two cytotoxic T lymphocyte epitopes (E7(11-20) and E7(86-93)) encoded by the human papillomavirus type 16 E7 (HPV16 E7) oncoprotein, which is a tumor-specific antigen for cervical carcinoma. This study reports that the two HPV16 epitopes and a control hepatitis B virus epitope bind… CONTINUE READING