Differential binding of tetrodotoxin and its derivatives to voltage‐sensitive sodium channel subtypes (Nav1.1 to Nav1.7)

@article{Tsukamoto2017DifferentialBO,
  title={Differential binding of tetrodotoxin and its derivatives to voltage‐sensitive sodium channel subtypes (Nav1.1 to Nav1.7)},
  author={Tadaaki Tsukamoto and Yukie Chiba and Minoru Wakamori and Tomoshi Yamada and Shunsuke Tsunogae and Yuko Cho and Ryo Sakakibara and Taku Imazu and Shouta Tokoro and Yoshiki Satake and Masaatsu Adachi and Toshio Nishikawa and Mari Yotsu-Yamashita and Keiichi Konoki},
  journal={British Journal of Pharmacology},
  year={2017},
  volume={174},
  pages={3881 - 3892}
}
The development of subtype‐selective ligands to inhibit voltage‐sensitive sodium channels (VSSCs) has been attempted with the aim of developing therapeutic compounds. Tetrodotoxin (TTX) is a toxin from pufferfish that strongly inhibits VSSCs. Many TTX analogues have been identified from marine and terrestrial sources, although their specificity for particular VSSC subtypes has not been investigated. Herein, we describe the binding of 11 TTX analogues to human VSSC subtypes Nav1.1–Nav1.7. 
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