Differential binding of ligands to the apolipoprotein E receptor 2.

@article{Andersen2003DifferentialBO,
  title={Differential binding of ligands to the apolipoprotein E receptor 2.},
  author={Olav Michael Andersen and David Benhayon and Tom Curran and Thomas E. Willnow},
  journal={Biochemistry},
  year={2003},
  volume={42 31},
  pages={
          9355-64
        }
}
Apolipoprotein E receptor 2 (apoER2) is an important participant in the Reelin signaling pathway that directs cell positioning during embryogenesis. ApoER2 is a cell surface molecule that elicits intracellular signal transduction through binding of Reelin. The structural requirements for Reelin binding to apoER2 and the receptor domains involved in this process are unclear at present. Using a series of receptor mutants, we characterized the interaction of apoER2 with Reelin and compared this… CONTINUE READING
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