Differential binding of cytokines to environmentally relevant particles: a possible source for misinterpretation of in vitro results?

@article{Kocbach2008DifferentialBO,
  title={Differential binding of cytokines to environmentally relevant particles: a possible source for misinterpretation of in vitro results?},
  author={Anette Kocbach and Annike Irene Totlandsdal and Marit L{\aa}g and Magne Refsnes and P E Schwarze},
  journal={Toxicology letters},
  year={2008},
  volume={176 2},
  pages={131-7}
}
Inflammation is considered as a key event in adverse health effects associated with exposure to ambient particulate matter. The inflammatory potential of particles is often compared using in vitro cell systems, where the particle-induced release of pro-inflammatory cytokines is measured. A major concern in these assays is the potential of particles to bind cytokines, which may lead to an underestimation of the inflammatory potential. We therefore investigated the cytokine binding to a selection… CONTINUE READING