Differential binding and internalization of insulin-like growth factor (IGF)-I in cultured human trophoblast and JEG-3 cells: possible modulatory effect of IGF binding proteins (BP)

The present study was undertaken to characterize and identify the insulin-like growth factor binding proteins (IGF BPs) secreted by placental cells and their possible modulatory effect on IGF-I binding to cell surface receptors. The experimental approach taken was comparative characterization of binding and internalization of IGF-I and its analog, [Gln3… (More)