Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat

@article{Daws2000DifferentialBA,
  title={Differential behavioural and neurochemical effects of para-methoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat},
  author={Lynette C. Daws and Rodney James Irvine and Paul Callaghan and Natasha P. Toop and Jason M. White and Felix Bochner},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2000},
  volume={24},
  pages={955-977}
}
  • L. Daws, R. Irvine, +3 authors F. Bochner
  • Published 2000
  • Medicine, Chemistry
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
1. This study was prompted by recent deaths that have occurred after recreational administration of the substituted amphetamine para-methoxyamphetamine (PMA). Because relatively little is known regarding its mechanism(s) of action, its effects on physiological, behavioural and neurochemical parameters were compared with the well known effects of 3,4-methylenedioxymethamphetamine (MDMA). 2. Equivalent doses of PMA (5-20 mg/kg) produced greater hypothermia than MDMA at an ambient temperature of… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
TLDR
The data suggest that, at relatively warm Ta's, MDMA-induced stimulation of serotonergic pathways causes an elevation in MR and peripheral vasoconstriction, thus producing life-threatening elevations in Tc, which is consistent with preliminary studies using radiotelemetry methodology. Expand
Comparative actions of monomethoxyamphetamines on the release and uptake of biogenic amines in brain tissue.
TLDR
The high potency of PMA on increasing the release and inhibiting the uptake of 3H-5-HT suggests than 5-HT may be involved in the production of hallucinogenic effects ofPMA. Expand
Effects of (±)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats
TLDR
It is concluded that acute treatment with high but not low doses of MDMA has a weak amphetamine-like effect on nigrostriatal as well as mesolimbic/mesocortical and tuberoinfundibular DA neurons in rats. Expand
The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.
TLDR
This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent. Expand
Comparison of cardiovascular, hyperthermic, and toxic effects of para-methoxyamphetamine (PMA) and 3, 4-methylenedioxyamphetamine (MDA).
TLDR
In male albino mice, determination of 6 hr LD50's indicated PMA to be most toxic although 24 hrLD50's showed nearly equal toxicity. Expand
Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine.
TLDR
MDMA-induced corticosterone secretion and hyperthermia were blocked by the 5-hydroxytryptamine (5-HT) antagonists, ketanserin and mianserin, which have a high affinity for 5-HT2 binding sites. Expand
Comparative effects of dl-p-methoxyamphetamine and d-amphetamine on catecholamine release and reuptake in vitro.
TLDR
The results suggest that the relatively weak effect of PMA on catecholamine release and reuptake in structures rich in DA-containing neurons may be related to the lack of effect ofPMA on locomotor activity and stereotyped behaviors. Expand
Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes.
TLDR
The enantiomers of 3,4-(methylenedioxy)amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their alpha, alpha-dimethylated derivatives, were evaluated for an effect on the release of [3H]serotonin from rat whole brain synaptosomes and suggested that transmitter release may play a role in the biological activity of MDMA. Expand
Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan.
TLDR
The data from the drug discrimination study and the behavioral syndrome induced by MMAI suggest that MMAI is a potential selective releaser of serotonin, and that endogenous 5-HT is essential for MMAI discrimination. Expand
Effect of para-methoxyamphetamine on catecholamine metabolism in the mouse brain.
TLDR
PMA was found to be ineffective in altering the levels of mouse brain DA and NE at doses of 3 and 10mg/kg but a significant decrease in these amines was observed at 30 mg/kg, while all doses of PMA tested markedly elevated brain5-HT and decreased brain 5-HIAA. Expand
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5
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