Differential behavioral responses of the spontaneously hypertensive rat to methylphenidate and methamphetamine: lack of a rewarding effect of repeated methylphenidate treatment.

@article{Pea2012DifferentialBR,
  title={Differential behavioral responses of the spontaneously hypertensive rat to methylphenidate and methamphetamine: lack of a rewarding effect of repeated methylphenidate treatment.},
  author={Ike C Dela Pe{\~n}a and Jong Chan Lee and Han Lim Lee and Tae Seon Woo and Hae Chang Lee and Aee Ree Sohn and Jae Hoon Cheong},
  journal={Neuroscience letters},
  year={2012},
  volume={514 2},
  pages={189-93}
}
Several questions remain unanswered concerning the effects of long-term methylphenidate treatment in individuals with attention-deficit/hyperactivity disorder (ADHD). It has been speculated that repeated methylphenidate treatment may facilitate abuse of the drug or psychological dependence. In the present study, we conducted conditioned place preference (CPP) tests to investigate whether the repeated treatment of methylphenidate results to greater "liking" of the drug. We compared the effect of… CONTINUE READING