Differential association of receptor-Gβγ complexes with β-arrestin2 determines recycling bias and potential for tolerance of δ opioid receptor agonists.

@article{Audet2012DifferentialAO,
  title={Differential association of receptor-Gβγ complexes with β-arrestin2 determines recycling bias and potential for tolerance of δ opioid receptor agonists.},
  author={Nicolas Audet and Iness Charfi and Ouissame Mnie-Filali and Mohammad Amraei and Anne-Julie Chabot-Dor{\'e} and Magali Millecamps and Laura S. Stone and Graciela Pi{\~n}eyro},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 14},
  pages={4827-40}
}
Opioid tendency to generate analgesic tolerance has been previously linked to biased internalization. Here, we assessed an alternative possibility; whether tolerance of delta opioid receptor agonists (DORs) could be related to agonist-specific recycling. A first series of experiments revealed that DOR internalization by DPDPE and SNC-80 was similar, but only DPDPE induced recycling. We then established that the non-recycling agonist SNC-80 generated acute analgesic tolerance that was absent in… CONTINUE READING
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