Differential association of Plasmodium falciparum Na+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.

@article{Pelleau2011DifferentialAO,
  title={Differential association of Plasmodium falciparum Na+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.},
  author={St{\'e}phane Pelleau and Lionel Bertaux and S{\'e}bastien Briolant and Michael T. Ferdig and V{\'e}ronique Sinou and Bruno Pradines and Daniel Parzy and R. Jambou},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 12},
  pages={
          5834-41
        }
}
Plasmodium falciparum isolates with decreased susceptibility to quinine are increasingly being found in malaria patients. Mechanisms involved in this resistance are not yet understood. Several studies claim that alongside mutations in the Pfcrt and Pfmdr1 genes, the Pfnhe-1 Na(+)/H(+) exchanger polymorphism plays a role in decreasing susceptibility. However, conflicting results on the link between the Pfnhe-1 gene and quinine resistance arise from field- and culture-adapted isolates. We tested… CONTINUE READING
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