Differential apoptosis effects of primate lentiviral Vpr and Vpx in mammalian cells.

@article{Chang2000DifferentialAE,
  title={Differential apoptosis effects of primate lentiviral Vpr and Vpx in mammalian cells.},
  author={L J Chang and Cheng Hsin Chen and Vlada B Urlacher and Todd Lee},
  journal={Journal of biomedical science},
  year={2000},
  volume={7 4},
  pages={322-33}
}
The growth inhibitory effects of Vpr and Vpx are species- and cell type-dependent. HIV-1, HIV-2 and SIV Vpr are primarily cytostatic in mammalian cells and HIV-1 Vpr has been reported to induce apoptosis in human cells. Our previous studies have shown that HIV-1, HIV-2 and SIV Vpr and Vpx have differential cytostatic and cytotoxic effects in the yeast cells… CONTINUE READING