Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat

@article{Terry2005DifferentialAO,
  title={Differential antagonism of the effects of dopamine D1-receptor agonists on feeding behavior in the rat},
  author={Philip Terry and Jonathan L. Katz},
  journal={Psychopharmacology},
  year={2005},
  volume={109},
  pages={403-409}
}
  • P. Terry, J. Katz
  • Published 2005
  • Biology, Psychology, Medicine
  • Psychopharmacology
A series of experiments was conducted to examine the effects of dopamine D1 receptor agonists on food intake in rats. In the first experiment, the D1 agonist SKF 38393 (3.0–30.0 mg/kg) dose-dependently suppressed feeding during a 40 min food-access period, both in food-deprived rats and in non-deprived rats fed a highly palatable diet. Non-deprived rats were more sensitive to these effects of SKF 38393. Using the limited-access, food-deprivation procedure, a comparison was made between the… 
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TLDR
The results support the view that the behavioral effects of D1-like receptor agonists differ in their susceptibility to antagonism by D1 -like receptor antagonists, and that some effects of SKF 38393 may be mediated by serotonergic activity rather than by activity at D1–like receptors.
A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393
TLDR
The generality of the D1 antagonist-mediated effect on feeding is demonstrated and the use of SKF 38393 as a D1 agonist in studies of feeding is called into question, and perhaps in other contexts as well.
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Effects of the prototypical D1 agonist previously unobserved are demonstrated, and questions concerning the nature of agonist/antagonist interactions at the D1 receptor subtype are raised.
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The “selective” dopamine D1 agonist, SKF 38393, has behavioral effects that cannot be antagonized by either a D1 or D2 antagonist, suggesting that some other mechanism has a significant role in mediating its behavioral effects.
A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice
Respective roles of dopamine D2 and D3 receptors in food-seeking behaviour in rats
TLDR
The results indicate that reinstatement of non-reinforced responding by non-contingent food delivery and by dopamine agonists probably depend on different mechanisms.
Comparison of the discriminative-stimulus effects of SKF 38393 with those of other dopamine receptor agonists
TLDR
The present results suggest that second messenger effects other than stimulation of adenylyl cyclase may play an important role in the behavioral effects of dopamine D1-like agonists.
Comparison of the discriminative-stimulus effects of SKF 38393 with those of other dopamine receptor agonists
TLDR
The present results suggest that second messenger effects other than stimulation of adenylyl cyclase may play an important role in the behavioral effects of dopamine D1-like agonists.
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TLDR
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  • Biology, Medicine
    Psychopharmacology
  • 2005
TLDR
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TLDR
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